Reference-grade research compound
PT 141
Bremelanotide, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, a cyclic lactam heptapeptide analog of α-melanocyte-stimulating hormone
Schematic — no PDB structure deposited
- Scientific name
- Bremelanotide, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH, a cyclic lactam heptapeptide analog of α-melanocyte-stimulating hormone
- Sequence
- —
- Length
- 7-mer
- Molecular formula
- C50H68N14O10
- Molecular weight
- 1025.20 g/mol
- Form
- lyophilized
- Vial size
- 10 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.1%
Description
A cyclic lactam-bridged heptapeptide analog of α-melanocyte-stimulating hormone, structurally derived from melanotan II by replacement of the C-terminal amide with a free carboxyl group. Used in vitro as a reference compound in melanocortin MC3R and MC4R receptor binding and signaling assays in transfected cell-line model systems. Supplied as a lyophilized acetate salt.
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
Melanocortin Receptor Agonist Bremelanotide Induces Cell Death and Growth Inhibition in Glioblastoma Cells via Suppression of Survivin Expression.
Anticancer Res · 2024
PMID 39197897PubMedPT-141 Palatin.
Curr Opin Investig Drugs · 2004
PMID 15134289PubMedBremelanotide: First Approval.
Drugs · 2019
PMID 31429064PubMed
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