Reference-grade research compound
Melanotan 2
Melanotan II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, a cyclic lactam heptapeptide analog of α-melanocyte-stimulating hormone
Schematic — no PDB structure deposited
- Scientific name
- Melanotan II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2, a cyclic lactam heptapeptide analog of α-melanocyte-stimulating hormone
- Sequence
- —
- Length
- 7-mer
- Molecular formula
- C50H69N15O9
- Molecular weight
- 1024.20 g/mol
- Form
- lyophilized
- Vial size
- 10 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.7%
Description
A cyclic lactam-bridged heptapeptide analog of α-melanocyte-stimulating hormone incorporating a norleucine substitution and a D-phenylalanine residue. Used in vitro as a reference compound in melanocortin MC1R, MC3R, MC4R, and MC5R receptor binding and signaling assays in transfected cell-line model systems. Supplied as a lyophilized acetate salt.
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat.
Eur J Pharmacol · 2003
PMID 12591111PubMedMelanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.
Int J Impot Res · 2000
PMID 11035391PubMedMelanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.
Neuropeptides · 2022
PMID 36155088PubMed
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