Reference-grade research compound
Melanotan 1 (MT-1)
Afamelanotide, [Nle4, D-Phe7]-α-MSH, Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Schematic — no PDB structure deposited
- Scientific name
- Afamelanotide, [Nle4, D-Phe7]-α-MSH, Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
- Sequence
- —
- Length
- 13-mer
- Molecular formula
- C78H111N21O19
- Molecular weight
- 1646.90 g/mol
- Form
- lyophilized
- Vial size
- 10 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.8%
Description
A linear 13-residue analog of α-melanocyte-stimulating hormone bearing a norleucine substitution at position 4 and a D-phenylalanine substitution at position 7, with a C-terminal amide. Used in vitro as a reference compound in melanocortin MC1R receptor binding and melanogenesis gene-expression assays in cell-line model systems. Supplied as a lyophilized acetate salt.
Current batch
RR-MELANOTAN1MT1-260316-B
Manufactured Mar 16, 2026
Tested Mar 22, 2026
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
[Nle4, D-Phe7]-α-MSH Inhibits Toll-Like Receptor (TLR)2- and TLR4-Induced Microglial Activation and Promotes a M2-Like Phenotype.
PLoS One · 2016
PMID 27359332PubMedPharmacokinetics and Pharmacodynamics of Afamelanotide and its Clinical Use in Treating Dermatologic Disorders.
Clin Pharmacokinet · 2017
PMID 28063031PubMedAfamelanotide.
2012
PMID 38598652PubMed
Titles and journals pulled from PubMed and cached for 7 days. Links open in a new tab.