Reference-grade research compound
CJC 1295 NO DAC
Tetrasubstituted analog of human growth-hormone-releasing factor (1-29), modified GRF(1-29)
Schematic — no PDB structure deposited
- Scientific name
- Tetrasubstituted analog of human growth-hormone-releasing factor (1-29), modified GRF(1-29)
- Sequence
- —
- Length
- 29-mer
- Molecular formula
- C152H252N44O42
- Molecular weight
- 3367.90 g/mol
- Form
- lyophilized
- Available sizes
- 2 mg, 5 mg, 10 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.2%
Description
A 29-residue analog of the growth-hormone-releasing factor (1-29) fragment carrying four amino-acid substitutions that increase resistance to enzymatic degradation; the sequence includes a D-Ala residue and a C-terminal amide. Used in vitro as a reference compound in pituitary cell-line growth-hormone release assays and GHRH-receptor binding model systems. Supplied as a lyophilized acetate salt.
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.
Endocrinology · 2005
PMID 15817669PubMedOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.
Am J Physiol Endocrinol Metab · 2006
PMID 16822960PubMedAdvances in the detection of growth hormone releasing hormone synthetic analogs.
Drug Test Anal · 2021
PMID 34665524PubMed
Titles and journals pulled from PubMed and cached for 7 days. Links open in a new tab.