Reference-grade research compound
CJC 1295 DAC
Drug affinity complex GHRH analog; tetrasubstituted 30-residue analog of human GHRH(1-29) with a Lys30 maleimidopropionyl drug-affinity-complex moiety
Schematic — no PDB structure deposited
- Scientific name
- Drug affinity complex GHRH analog; tetrasubstituted 30-residue analog of human GHRH(1-29) with a Lys30 maleimidopropionyl drug-affinity-complex moiety
- Sequence
- —
- Length
- 30-mer
- Molecular formula
- C165H269N47O46
- Molecular weight
- 3647.15 g/mol
- Form
- lyophilized
- Available sizes
- 2 mg, 5 mg, 10 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.1%
Description
Tetrasubstituted 30-residue analog of human growth hormone-releasing hormone (1-29) bearing a C-terminal lysine conjugated to a maleimidopropionyl drug-affinity-complex group that promotes albumin binding. Used in vitro as a reference compound in GHRH receptor binding and cAMP accumulation assays in pituitary cell-line model systems. Supplied as a lyophilized acetate salt.
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
Human growth hormone-releasing factor (hGRF)1-29-albumin bioconjugates activate the GRF receptor on the anterior pituitary in rats: identification of CJC-1295 as a long-lasting GRF analog.
Endocrinology · 2005
PMID 15817669PubMedProlonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults.
J Clin Endocrinol Metab · 2006
PMID 16352683PubMedOnce-daily administration of CJC-1295, a long-acting growth hormone-releasing hormone (GHRH) analog, normalizes growth in the GHRH knockout mouse.
Am J Physiol Endocrinol Metab · 2006
PMID 16822960PubMed
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