Reference-grade research compound
Ara-290
Cibinetide (ARA-290); Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH, an 11-residue erythropoietin-derived peptide
Schematic — no PDB structure deposited
- Scientific name
- Cibinetide (ARA-290); Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser-OH, an 11-residue erythropoietin-derived peptide
- Sequence
- —
- Length
- 11-mer
- Molecular formula
- C51H84N16O21
- Molecular weight
- 1257.31 g/mol
- Form
- lyophilized
- Vial size
- 10 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.1%
Description
Linear 11-residue peptide derived from the helix B region of erythropoietin, bearing an N-terminal pyroglutamate. Used in vitro as a reference compound in innate repair receptor (EPOR/CD131) binding assays and anti-inflammatory cell-culture model systems. Supplied as a lyophilized acetate salt.
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
Cibinetide dampens innate immune cell functions thus ameliorating the course of experimental colitis.
Sci Rep · 2017
PMID 29026145PubMedThe Non-Erythropoietic EPO Analogue Cibinetide Inhibits Osteoclastogenesis In Vitro and Increases Bone Mineral Density in Mice.
Int J Mol Sci · 2021
PMID 35008482PubMedActivation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes.
Biochim Biophys Acta Mol Basis Dis · 2018
PMID 29223734PubMed
Titles and journals pulled from PubMed and cached for 7 days. Links open in a new tab.