Reference-grade research compound
AICAR
Acadesine; 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide (AICA riboside)
Schematic — no PDB structure deposited
- Scientific name
- Acadesine; 5-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamide (AICA riboside)
- Sequence
- —
- Length
- 0-mer
- Molecular formula
- C9H14N4O5
- Molecular weight
- 258.23 g/mol
- Form
- lyophilized
- Vial size
- 50 mg
- Storage
- Store powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.2%
Description
Small-molecule purine nucleoside analog and cell-permeable AMP-activated protein kinase activator. Used in vitro as a reference compound in AMPK signaling and cellular metabolism assays in cultured cell-line model systems. Supplied as a lyophilized powder.
Storage and stability
Store powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes.
Diabetes · 2000
PMID 11016448PubMedAICAR promotes endothelium-independent vasorelaxation by activating AMP-activated protein kinase via increased ZMP and decreased ATP/ADP ratio in aortic smooth muscle.
J Basic Clin Physiol Pharmacol · 2022
PMID 35503763PubMedAICAR confers prophylactic cardioprotection in doxorubicin-induced heart failure in rats.
J Mol Cell Cardiol · 2024
PMID 38643934PubMed
Titles and journals pulled from PubMed and cached for 7 days. Links open in a new tab.