Reference-grade research compound
Ace-031 95%
ACE-031 (ramatercept), a recombinant dimeric fusion protein of the human ACVR2B extracellular domain linked to human IgG1 Fc
Schematic — no PDB structure deposited
- Scientific name
- ACE-031 (ramatercept), a recombinant dimeric fusion protein of the human ACVR2B extracellular domain linked to human IgG1 Fc
- Sequence
- —
- Length
- 0-mer
- Molecular formula
- Recombinant dimeric Fc-fusion glycoprotein (~110 kDa)
- Molecular weight
- 110000.00 g/mol
- Form
- lyophilized
- Vial size
- 1 mg
- Storage
- Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
- Batch HPLC purity
- 99.1%
Description
Recombinant dimeric fusion protein joining the extracellular ligand-binding domain of human activin receptor type IIB (ACVR2B) to a human IgG1 Fc region, functioning as a soluble decoy receptor for TGF-β superfamily ligands. Used in vitro as a reference compound in myostatin and activin ligand-trap binding assay model systems. Supplied as a lyophilized solid at 95% purity.
Storage and stability
Store lyophilized powder at −20 °C, desiccated and protected from light. Stable for 24 months.
Peer-reviewed references
Myostatin/Activin Receptor Ligands in Muscle and the Development Status of Attenuating Drugs.
Endocr Rev · 2022
PMID 34520530PubMedAn antibody blocking activin type II receptors induces strong skeletal muscle hypertrophy and protects from atrophy.
Mol Cell Biol · 2014
PMID 24298022PubMedActivin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans.
J Appl Physiol (1985) · 2007
PMID 17347381PubMed
Titles and journals pulled from PubMed and cached for 7 days. Links open in a new tab.